Energy-demanding processes, such as migration, phagocytosis, and the generation of an oxidative burst, that accompany the recruitment of the heterophils to the site of infection, trigger transcriptional and translational changes in tissue phenotype (predominately the metabolic signaling pathway of mTOR phosphorylation) that shifts fundamental changes to the local intestinal tissue to anabolic metabolism (37–39). The gene discussed is MTOR; the disease is infection.