Examples are MEFV/pyrin in familial Mediterranean fever (FMF), TNFRSF1A/TNF receptor type 1 in TNF receptor-associated periodic syndrome (TRAPS), and nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing 3 (NLRP3) in cryopyrin-associated periodic syndromes (CAPS) (2). This evidence concerns the gene NLRP3 and cryopyrin-associated periodic syndrome.