NLRP3 and cryopyrin-associated periodic syndrome: Since 2001, mutations in the NACHT domain of the NLPR3/CIAS1 gene were linked to FCAS and MWS (49, 50), whereas mutations in the same gene were identified in 2002 in sporadic cases with NOMID/CINCA (48, 51); after these evidences, the three disorders were grouped under the family of CAPS.