NLRP3 and familial cold autoinflammatory syndrome: Familial cold autoinflammatory syndrome (OMIM 120100), MWS (OMIM 191900), and CINCA syndrome (OMIM 607115), also known as neonatal onset multisystem inflammatory disease (NOMID), are autosomal dominant disorders (45–47) caused by mutations in the NLRP3 (NOD-like receptor 3, cold-induced autoinflammatory syndrome 1, also named CIAS1) gene, encoding for the cryopyrin protein, an important inflammasome protein that directly activates IL-1β (48).