Because CO is able to inhibit TLR4 signaling (Figure 1B) and because KSHV infection activates TLR4 signaling (Lagos et al., 2008), we next tested whether the expression of IL-1β and IFNβ in KSHV-infected iLEC could be reduced by delivering CO to iLEC immediately prior to infection. The gene discussed is IL1B; the disease is infection.