We began by validating our prior observations (Botto et al., 2015), reconfirming that KSHV-infected iLEC exhibit a transient peak of HO-1 message between 4 and 6 h post-infection (hpi) and that this early HO-1 induction is observed regardless of whether the viral inoculum is live- or UV-inactivated (Figure 1A). The gene discussed is HMOX1; the disease is infection.