CAV1 and systemic sclerosis: Through its ability to act as a surrogate for caveolin-1, CSD can reverse a variety of cell behaviors associated with fibrosis in vitro (collagen overexpression by SSc fibroblasts, enhanced migration and enhanced fibrocyte differentiation by AA and SSc monocytes (Tourkina et al., 2005, 2011; Reese et al., 2014b) and in vivo (enhanced lung and dermal fibrosis, loss of subcutaneous adipocytes, Lee et al., 2015).