TNF and breast carcinoma: However, curcumin pre-treatment for 5 days in cisplatin-treated rats significantly reduced the levels of TNF-α (p < 0.001), IL-6 (p < 0.01), and IL-8 (p < 0.05) whereas significantly improved the level of IL-10 (p < 0.001) as compared to cisplatin-treated breast cancer rats (Figure 3).