In tertile analysis, no significant differences were observed between serum Cav-3 in medical history (CAD, hypertension, DM, etc), clinical parameters (NT-pro BNP, CRP, Creatinine clearance rate, etc) and echocardiographic measurements (left ventricular end-diastolic dimension and LVEF) among the three groups. This evidence concerns the gene NPPB and hypertensive disorder.