When the data were KEGG-analyzed with intersection of co-localization and co-expression of genes of DE lncRNAs, target genes of DE miRNAs and predicted mRNAs, the most significantly involved pathways in SNI pathogenesis were ribosome, Phosphatidyl Inositol 3-kinase (PI3K)-Akt signaling pathway, focal adhesion, extracellular matrixc (ECM)-receptor interaction, amoebiasis and protein digestion and absorption (Figure 12A). Here, AKT1 is linked to amebiasis.