To this end, using cell-specific microarrays in CD11b+ microglia, we recently identified DNA damage pathway and in particular the tumor suppressor gene breast cancer susceptibility gene 1 (Brca1) upregulation in an animal model of amyotrophic lateral sclerosis (ALS) (Noristani et al., 2015b). This evidence concerns the gene BRCA1 and amyotrophic lateral sclerosis.