Interestingly, silencing CDK5 decreases the hyperreactivity of astrocytes at 1 month post-treatment (Gutiérrez-Vargas et al., 2015) but increased astrocytic arborization under neuroprotective conditions at 4 months post-ischemia (Gutiérrez-Vargas et al., 2016). The gene discussed is CDK5; the disease is ischemia.