SNCA and Parkinson disease: PD can arise from autosomal dominant mutations associated with the alpha-synuclein gene, SNCA, resulting in A53T, H50Q, E46K, A53E, G51D, and A30P variants (Wirdefeldt et al., 2011; Nussbaum, 2017) and has also been linked to alpha-synuclein overexpression, accumulation and aggregation (Shin et al., 2009; Anandhan et al., 2015; Van der Perren et al., 2015).