IL27 and colitis: In T cell-dependent murine colitis model, EBI3−/− mice (lacking both IL-27 and IL-35) develop early onset and severe colitis with shorten survival time, when compared to IL-27p28−/− mice (lacking IL-27 only) [65], while recombinant IL-35 treatment significantly limited the development of several forms of experimental colitis and decreased levels of markers of Th1 and Th17 cells [65].