Visperas et al. showed that IL-27Rα−/−TCRβ−/− recipients did not develop intestinal inflammation after naive CD4+T cell infusion because these recipient mice had poor Th17 differentiation and lower expression of IL-6 and IL-1β by antigen-presenting cells; while IL-27Rα+/+TCRβ−/− recipients developed severe colitis after naive CD4+T cell infusion [60]. Here, CD4 is linked to inflammatory response.