In ovarian tumor-bearing mice, blood IL-6 levels increased (P < 0.01) after treatment with CDDP alone or pHLIP-control PNA + CDDP, and IL-6 blood levels were reduced (P < 0.05) after pHLIP-PNA3 + CDDP treatment compared to pHLIP-PNA control + CDDP (Fig. 4F). Here, IL6 is linked to ovarian neoplasm.