With regard to this, the expression of T-helper1 cytokines such as IL-1α, IL-1β, IL-2, and interferon (IFN)-γ in tumor tissue is associated with good prognosis, whereas T-helper2 cytokines such as IL-4, IL-5, and IL-10 are upregulated in aggressive disease [8]. The gene discussed is IFNG; the disease is neoplasm.