EGFR and disease arising from reactivation of latent virus: They are generally considered to be induced by receptor-ligand engagement during the viral entry process (via gB and gH complex binding to appropriate cognate ligands—epidermal growth factor receptor [EGFR] and select integrins [6] [Fig. 1A]) and are thought to be key to viral dissemination in infected myeloid cells following primary and latent infection (7, 8).