The protein derived from the TCF7L2 (transcription factor 7-like 2) gene, also known as the TCF4, is an important transcription factor in the Wnt signaling pathway [8], which was initially characterized in colon cancer and in the embryonic development of Drosophila, Xenopus, and other organisms [9]. The gene discussed is TCF7L2; the disease is colonic neoplasm.