BCL2 and pituitary adenocarcinoma: Higher mitotic activity [3], cellular pleomorphism and/or hyperchromasia [3], miR20a and miR-17-5p upregulation [8], increased galectin-3 expression [24], decreased p27 expression [21], increased frequency of aneuploidy [3], decreased β-catenin expression [25], decreased BCL2 expression [22], and increased topoisomerase-2α expression [26] have all been associated with APAs or their progression to pituitary carcinoma.