Taken together, our data demonstrate that lncRNA uc.134 plays a key role in suppressing the proliferation, invasion, and metastasis of HCC by blocking CUL4A nuclear export to ubiquitinate LATS1 and increasing YAPS127 phosphorylation, which implicates the lncRNA uc.134-CUL4A-Hippo axis as a potential therapeutic target for the treatment of HCC. This evidence concerns the gene CUL4A and hepatocellular carcinoma.