Indeed in a recent study, differentiated beta cells derived in vitro from human iPSC were shown to secrete insulin in a glucose-responsive manner in vivo when transplanted and encapsulated in immunodeficient NOD-Rag1nullIL2rgnullIns2Akita (NRG-Akita) mice and overcame progressively worsening hyperglycemia in these mice over several months [9]. This evidence concerns the gene INS and Hyperglycemia.