While several studies using pluripotent stem cells have shown their potential for differentiating into insulin-producing beta cells, including via ectodermal commitment [8, 11, 31, 45, 46] (reviewed in [1, 13, 14, 35]), few have shown a short-term ability of insulin-producing beta-like cells to decrease STZ-induced hyperglycemia in vivo when transplanted into encapsulated structures in immunodeficient mouse models of T1DM [9, 20] (reviewed in [13, 14]). This evidence concerns the gene INS and type 1 diabetes mellitus.