FLT3 and acute myeloid leukemia: In a phase 1b study of newly diagnosed young (≤60 years) AML patients, a midostaurin 50-mg twice-daily dose schedule in combination with 7 + 3 and high-dose cytarabine (HDAC) post-remission resulted in CR rates of 92 and 74% in patients with FLT3-mutant and FLT3-wild-type AML, respectively [62].