Finally, interim results of a phase 2 trial of crenolanib in combination with salvage idarubicin and HDAC in multiply R/R FLT3-mutated AML showed a CRc rate of 67% from a total of six patients who received ≤2 prior AML therapies, while no one with >2 prior treatments achieved CR [73]. Here, FLT3 is linked to acute myeloid leukemia.