Our previous study demonstrated that Bach1 knockout inhibited the progression of BLM-induced pulmonary fibrosis by regulating the expressions of Nrf2 and its downstream anti-oxidant factors including Ho-1 and Gpx1, thus providing novel insights into the role of Bach1/Nrf2 in the regulation of oxidative stress involved in the pathogenesis of IPF [20]. The gene discussed is BACH1; the disease is idiopathic pulmonary fibrosis.