Our results further suggested that PFD regulated the equilibrium of Nrf2/Bach1 and expression of a Nrf2-dependent antioxidant factor, further mitigating the inhibitory effect of antioxidant level in TGF-β1 induced MLF and in mice with BLM-induced pulmonary fibrosis, thus facilitating the antioxidant effect. Here, NFE2L2 is linked to pulmonary fibrosis.