In this regard, we have developed a methodology to quantify the ratio of core fucosylation of serum PSA and the percentage of α2,3-sialic acid of serum PSA and have shown a decrease in the content of core fucose and an increase in α2,3-sialic acid of PSA N-glycans in patients with high-risk PCa [9]. This evidence concerns the gene KLK3 and posterior cortical atrophy.