SMPD1 and Sepsis: The parameter E’ (Figure 1F) revealed significant impaired diastolic function in SMPD1+/+ at 6 h (baseline: 34.23 ± 8.12 vs. 14.08 ± 1.43 mm/s, p ≤ 0.05) and 24 h (24.23 ± 1.34 mm/s, p ≤ 0.05) as compared to baseline values following sepsis, whereas diastolic dysfunction was less pronounced in both pretreated strata.