Both SMPD1+/+ (baseline: 1.87 ± 0.68 vs. 1.12 ± 0.13, p ≤ 0.05) and SMPD1−/− animals (baseline: 1.79 ± 0.4 vs. 1.15 ± 0.37, p = 0.057) displayed a reduction of MV E/A at 6 h following polymicrobial sepsis as compared to baseline values (Figure 1E). Here, SMPD1 is linked to Sepsis.