dSMPD1+/+, as well as dSMPD1−/− displayed no changes during sepsis at both time points, respectively, and significantly higher values were shown at 6 h in dSMPD1+/+ (1.73 ± 0.1, p ≤ 0.05) as compared to SMPD1+/+ at a similar time point. The gene discussed is SMPD1; the disease is Sepsis.