Glutathione levels decreased significantly in SMPD1+/+ from baseline to 24 h following sepsis (baseline: 787.2 (IQR 658.9–925.6 vs. 623.0 (IQR 616.7–628.5) μg/g, p ≤ 0.05; Figure 2A). Here, SMPD1 is linked to Sepsis.