SMPD1 and Sepsis: The pretreatment of SMPD1+/+ as well as SMPD1−/− animals with desipramine significantly increased baseline values as compared to SMPD1+/+ (dSMPD1+/+: 15,633 (IQR 12,167–23,493) pmol/g heart; dSMPD1−/−: 10,465 (IQR 7356–13,338) pmol/g, p ≤ 0.05 each), respectively, but completely abrogated its generation due to sepsis (dSMPD1+/+: 21,832 (IQR 16,309–28,691) pmol/g; dSMPD1−/−: 8539 (IQR 8210–12,596) pmol/g; 24 h).