SMPD1 and Sepsis: Sepsis resulted in a strong increase of troponin I serum levels in SMPD1+/+ in the acute phase (baseline: 13.3 (IQR 13.3–22.4) vs. 177.2 (IQR 105.2–332.6) pg/mL, p ≤ 0.01; Figure 3B).