SMPD1 and Sepsis: Interestingly, desipramine pretreatment of SMPD1−/− (612.0 (IQR 566.0–710.0) U/L, p ≤ 0.05) and SMPD1+/+ (610.0 (IQR 566.0–710.0) U/L, p ≤ 0.05) resulted in less pronounced elevation following sepsis induction as compared to untreated SMPD1+/+ animals (1395.0 (IQR 640.0–1885.0) U/L).