XDH and Sepsis: Due to the fact that desipramine pretreatment resulted in improved cardiac function in sepsis independent from acid sphingomyelinase, we found 11,620 gene transcripts of cardiac homogenates detectable comparing SMPD1+/+ and dSMPD1+/+, but 56 transcripts were found differentially expressed with False-Discovery-Rate (FDR) adjusted p-values ≤ 0.1 following polymicrobial sepsis, among others transcripts TNFaip8, Atp1b2, Prdx4, Eif4ebp1, and Xdh (Figure 5A).