However, desipramine pretreatment of SMPD1+/+ (baseline: 4.9 (IQR 4.5–5.6) vs. 5.4 (5.1–5.7), not significant (n.s.)) and SMPD1−/− animals (baseline: 5.4 (IQR 4.6–5.9) vs. 6.1 (IQR 5.4–6.9), n.s.)had no influence on the values during sepsis. The gene discussed is SMPD1; the disease is Sepsis.