SMPD1 and Sepsis: No differences in ejection fraction (Figure 1D) in SMPD1+/+ and SMPD1−/− were observed at 6 and 24 h following sepsis, whereas desipramine-pretreated (dSMPD1+/+) animals displayed a significantly improved EF at 6 and 24 h (baseline: 66.9 (IQR 52.8–77.8) vs. 6 h: 78.65 (IQR 74.2–82.1) vs. 24 h: 84.5 (IQR 84.3–85.4), p ≤ 0.05 vs. baseline as well as untreated SMPD1+/+) during sepsis.