SMPD1 and Sepsis: In Figure 4B, a 3.85-fold increase of C18-ceramide in heart tissue homogenates of SMPD1+/+ was demonstrated in the acute phase of sepsis (baseline: 3726 (IQR 2731–5790) vs. 12,748 (IQR 10,695–23,677) pmol/g, p ≤ 0.05).