C16-ceramide significantly increased in myocardial tissue homogenates in SMPD1+/+ from 12,629 (IQR 8900–22,254) pmol/g at baseline vs. 60,140 (IQR 59,697–68,968) pmol/g following polymicrobial sepsis (p ≤ 0.05, Figure 4A). This evidence concerns the gene SMPD1 and Sepsis.