SMPD1 and Sepsis: Therefore, we intended to clarify the role of SMPD1 in contributing to cardiac ceramide generation during sepsis using mice in which either the enzyme was totally absent through genetic knock-out (SMPD1−/−) or partially inhibited by a FIASMA (desipramine, d) (dSMPD1+/+ as well as dSMPD1−/−), compared to SMPD1+/+.