The GSH/GSSG ratio (Figure 2C) decreased in the untreated SMPD1+/+ group at 24 h following sepsis (baseline: 5.9 (IQR 5.7–6.2) vs. 5.3 (IQR 5.1–5.4), p ≤ 0.05) as well as in the untreated SMPD1−/− group (baseline: 6.0 (IQR 5.8–6.5) vs. 5.3 (IQR 4.5–5.3), p ≤ 0.05). Here, SMPD1 is linked to Sepsis.