SMPD1 and Sepsis: Pretreatment of SMPD1+/+ animals with desipramine resulted in significantly elevated baseline values (54,425 (IQR 59,697–68,968) pmol/g, p ≤ 0.05 vs. SMPD1+/+ at baseline), but abrogated the increase of ceramide generation following sepsis (77,879 (IQR 57,644–109,723) pmol/g).