SMPD1 and Sepsis: Glutathione levels (Figure 2B) decreased significantly in untreated SMPD1+/+ at 24 h following sepsis as compared to corresponding baseline animals (baseline: 588.5 (IQR 496.3–687.8) vs. 451.1 (IQR 443.8–457.0) μg/g, p ≤ 0.05).