The hypothesis that excessive intake of dietary sugars might interfere with lipid metabolism through the action of AGEs has been confirmed by the observation that the SREBP-activating protein SCAP is highly glycated by CML, a modification evoking prolonged activation of SCAP by inhibiting its degradation [12,52,62]. The gene discussed is SCAP; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.