BGLAP and obesity due to melanocortin 4 receptor deficiency: The anti-obesity, blood glucose control, cholesterol and insulin resistance lowering effects of black soybean either fermented or not were confirmed on animal models including hypercholesterolemic rabbits [130] and mice with high fat/cholesterol diet-induced obesity [131,132]; in addition, in ovariectomized mice, fermented black soybean supplementation lowered serum HDL-cholesterol, estradiol levels, serum alkaline phosphatase activity and osteocalcin levels, suggesting an osteoporosis preventive action [133].