When the GC cohort was categorized into 2 groups according to urinary levels of KLK10, the high uKLK10 group showed a significantly shorter DFS compared to the low uKLK10 group (1y-DFS, 63.8% vs. 84.4%, respectively, P<0.001; hazard ratio (HR): 3.30 [95% CI, 1.58-6.90]). The gene discussed is KLK10; the disease is gastric cancer.