In the current study, we showed that syntenin, a tandem PDZ-domain protein that induces tumor cell invasion and metastasis, functions as a positive regulator of VEGF-induced angiogenesis by enhancing VEGF-induced VEGFR2 endocytosis and subsequent activation of VEGFR2 signaling molecules in ECs (Figure 7E). Here, KDR is linked to neoplasm.