The largest fold difference in mRNA expression between tumor and non-tumor tissues was seen for SERPINB5 and KRT16. Because KRT16 protein expression has not been previously investigated in pancreatic cancer, we further conducted immunohistochemistry (IHC) to compare the expression level of KRT16 protein in eight pairs of tumor and adjacent non-tumor tissues from patients who underwent resection for PDAC. The gene discussed is SERPINB5; the disease is familial pancreatic carcinoma.