Treatment with OSU-A9 induced apoptosis, the down-regulation of Akt phosphorylation, the up-regulation of p38 phosphorylation, the inhibition of JAK and STAT3 phosphorylation, a reduction in pancreatic cancer cell aggressiveness, and the blocking of BxPC-3 xenograft growth in nude mice. This evidence concerns the gene MAPK14 and familial pancreatic carcinoma.