MMP2 and cancer: Since matrix metalloproteinases (MMP) are linked with cancer cell migration and invasion [24], we performed gelatin zymography to analyze the levels of secreted MMP-2 and MMP-9 following OSU-A9 treatment of BxPC-3 and PANC-1 cells for 24 h and found reduced MMP-2 and MMP-9 proteolytic activity (Figure 5D).