Subsequent univariate analysis (UA) and multivariate analysis (MA) revealed that, along with positive lymph node metastasis (P<0.001 for UA and P=0.023 for MA), overexpression of ZNF452 (P<0.001 for UA and P<0.001 for MA, Table 2) could be considered as independent prognostic factors in NSCLC patients. The gene discussed is SCAND3; the disease is non-small cell lung carcinoma.