SCAND3 and neoplasm: After overexpressing ZNF452 in A549 and depleting ZNF452 in H1299 cells, MTT and colony formation assay results suggested that upregulating ZNF452 expression enhanced tumor growth and colony formation abilities in A549 cells, whereas downregulating ZNF452 expression depressed tumor growth and colony formation abilities in H1299 cells (Figure 3A-3B).