To investigate the signaling pathways involved in the IL-6-mediated MDSCs differentiation, we examined the IL-6-induced activation of NF-κB (phosphorylation of p65) and Stat3 (phosphorylation of Stat3) pathways in CD11b+ myeloid cells in BC patients in T2-T4 and Ta-T1 stages. The gene discussed is NFKB1; the disease is breast cancer.