To the best of our knowledge, we are the first to analyse the association of the four CYP450 SNPs, including rs11636419, rs17861162, and rs2470890 in the CYP1A2 gene and rs12333983 in the CYP3A4 gene, with the clinicopathological features and prognosis of breast cancer patients. Here, CYP1A2 is linked to breast carcinoma.