Interestingly, normal CD19+ lymphocytes displayed a physiological localization of PTEN both in the nucleus and the cytosol (which we refer to as a “diffuse pattern”), while most of CLL CD19+ lymphocytes were characterized by PTEN nuclear exclusion (from an exclusively “cytosolic” PTEN to a “predominantly cytosolic” compartmentalization of PTEN) (Figure 5A and Supplementary Figure S9A). This evidence concerns the gene PTEN and B-cell chronic lymphocytic leukemia.