In the dominant genetic model of rs2274223, G (AG/GG) allele carriers also showed increased risk in HBV-related HCC with AFP cut-off levels of 200 and 400 ng/ml (AG/GG vs. AA; adjusted P=0.024, adjusted OR= 1.607, 95% CI= 1.065–2.424 for an AFP cut-off level of 200 ng/ml; and adjusted P= 0.028, adjusted OR= 1.588, 95% CI= 1.052–2.399 for an AFP cut-off level of 400 ng/ml) as compared to AA carriers. Here, AFP is linked to hepatocellular carcinoma.