Interestingly, there was no activation of the Src pathway, which is another important regulatory pathway in cancer cell invasion and metastasis [9, 10], as indicated by the comparable protein expression level of p-Src and Src between the I3 sublines and corresponding parental cells (Figure 2D), even though the IPA analysis also suggested the dysregulation of the Src pathway in KYSE410-I3 cells. The gene discussed is SRC; the disease is cancer.