Statistical analysis results showed that MTA3 expression level in colorectal cancer was significantly correlated to tumor differentiation, node metastasis, distant metastasis as well as TNM stage, since negative MTA3 staining was more likely to be detected in tumors with poor differentiation (P < 0.001), node metastasis (P < 0.001), distant metastases (P = 0.034) or advanced TNM stage (P < 0.001). This evidence concerns the gene MTA3 and colorectal cancer.