Corroborating the transcriptomic array data from a national cohort, the CXCL12 expression was strongly decreased in a local cohort of 23/30 adenomas and in 45/46 carcinomas at both the protein (Figure 2C–2D) and mRNA levels (adenomas: mean relative ratio: 0.28; p = 0.008; carcinomas: mean relative ratio: 0.18; p = 0.005; Figure 2E–2F). This evidence concerns the gene CXCL12 and adenoma.