TGFB1 and neoplasm: Many effects of TGF-β1 on the progression of breast cancer remain undetermined, such as epithelial-to-mesenchymal transition [28, 29], the crucial function of TGF-β1 as a modulator of matrix metalloproteinases [6, 30], and TGF-β1 mediated recruitment of tumor microenvironment [24, 31].