PPARGC1A and type 2 diabetes mellitus: In <65 years group, after adjustment for gender, alcohol use, smoking status and BMI by logistic regression analysis, the GA/AA and GA genotypes of PPARGC1A rs3736265 G>A polymorphism were also associated with a significantly decreased risk of T2DM compared with the GG genotype [GA+AA vs. GG: adjusted OR = 0.67, 95% CI 0.46–0.98, P = 0.038 and GA vs. GG: adjusted OR = 0.60, 95% CI = 0.40–0.90, P = 0.013 (Table 4)].