Therefore, in this study, we designed a hospital-based case-control study and selected PPARG rs1801282 C>G, PPARG rs3856806 C>T, PPARGC1A rs8192678 C>T, PPARGC1A rs2970847 C>T, PPARGC1A rs3736265 G>A, PPARGC1B rs7732671 G>C and PPARGC1B rs17572019 G>A polymorphisms to assess the relationship between these SNPs and T2DM in an Eastern Chinese Han population using the SNPscan method. Here, PPARGC1A is linked to type 2 diabetes mellitus.