In the analysis of PPARGC1A rs3736265 G>A polymorphism, differences in the frequency distribution of the GA/AA genotypes compared with the GG genotype and GA genotype compared with the GG genotype between T2DM patients and non-diabetic controls were found [GA+AA vs. GG: crude odds ratio (OR) = 0.76, 95% confidence interval (CI) = 0.59–0.99, P = 0.041 and GA vs. GG: crude OR = 0.76, 95% CI = 0.58–1.00, P = 0.049 (Table 3)]. This evidence concerns the gene PPARGC1A and type 2 diabetes mellitus.