PPARGC1A and type 2 diabetes mellitus: Several epidemiological investigations have explored the effects of PPARGC1A rs8192678G>A (Gly482Ser) and PPARGC1A rs2970847 C>T (Thr394Thr) in exon 8 and PPARGC1A rs3736265 G>A (Thr612Met) in exon 9 on the development of T2DM; however, the relationships have not been consistently replicated.