Haplotype comparison analysis indicated that CTTCGGG and CTCTGGG haplotypes with the order of PPARG rs1801282 C>G, PPARG rs3856806 C>T, PPARGC1A rs8192678 C>T, PPARGC1A rs2970847 C>T, PPARGC1A rs3736265 G>A, PPARGC1B rs7732671 G>C and PPARGC1B rs17572019 G>A polymorphisms in gene position significantly increased the risk of T2DM (OR = 1.39, 95% CI = 1.01–1.90; P = 0.041; and OR = 1.83, 95% CI = 1.22–2.75; P = 0.003, respectively). Here, PPARGC1B is linked to type 2 diabetes mellitus.