The Ewing sarcoma t(11;22)(q24;q12) translocation substitutes a putative RNA-binding domain of the Ewing sarcoma gene (EWS) on chromosome 22 for the DNA-binding domain-encoding region of FLI-1 on chromosome 11 to yield a chimeric transcription factor that requires the DNA binding domain encoded by FLI-1 for transformation. Here, EWSR1 is linked to Ewing sarcoma.