SLC2A1 and neoplasm: Four key observations in the present study provide evidence that the PSIC map can help identify tumor hypoxia: 1) the proportion of tumor with a low PSIC (PSIC<10%) was strongly correlated with GLUT-1 expression and necrosis; 2) high PSIC was significantly correlated with high vessel density; 3) the survival times of rats grouped according to the percentage of tumor area with low PSIC differed significantly; and 4) PSIC was significantly correlated with pO2 changes in subcutaneous tumors.