To identify whether the variants of methylated or acetylated signals in histone 3 on the promoter region of UGT2B7 may join in this phenomenon, two histone transferase inhibitors, BIX-01294 and TSA, were applied in three different CRC cell lines, HCT-116, HCT-15 as well as SW620. This evidence concerns the gene UGT2B7 and colorectal carcinoma.