Treatment ESCC or acute myelogenous leukemia cells with MLN4924, a neddylation inhibitor, lead to inactivation of CRL/SCF E3 ubiquitin ligase and transactivation of NOXA in a cell-type-specific manner to induce cell apoptosis [25, 33]. The gene discussed is PMAIP1; the disease is esophageal squamous cell carcinoma.