However, after subgroup analysis by study design stratification, we found that the BRCA2 rs144848 N372H polymorphism was associated with increasing the risk of breast cancer in population-based studies (H allele vs. N allele, OR = 1.034, 95% CI = 1.000-1.068, p = 0.047). The gene discussed is BRCA2; the disease is breast carcinoma.