SDC1 and Miyoshi myopathy: At present, CD138 magnetic bead separation combined with FISH technology have considerably improved the cytogenetic abnormalities detection of MM [20–21] Given these therapeutic innovation and technical improvement, R-ISS was proposed by IMWG in 2015 which combines ISS, LDH and high-risk cytogenetic abnormalities including t (4;14), t (14,16) and/or del (17p) [22].