ADORA2A and memory impairment: Although A2AR hypofunction enhances synaptic plasticity and memory function,16, 58, 59 hippocampal A2AR activation is implicated in memory impairment and cognitive decline.17 Our results indicate that A2AR hypofunction in combination with heightened states of reward seeking can maladaptively exacerbate impulsive behavior in contexts, where reward gratification is unpredictable.