PPP3CC and major depressive disorder: Decreased hippocampal expression has been found in 13 schizophrenia cases versus 12 controls.110 In two European ancestry samples, variants in PPP3CC were found to be nominally associated with treatment-resistant depression, antidepressant treatment response and remission (P-values ranging from 0.04 to 0.0002), and some of these effects were suggested to be through the B-cell receptor signaling pathway via pathway analysis (permutated P=0.03).111