To investigate whether the antiviral effect of C11orf83 is through OASs-RNase L system, we examined the expression of OAS family four members (OAS1, OAS2, OAS3, and OASL) at the mRNA level in HEK293 cells that only overexpressed C11orf83 but no viral infection. The gene discussed is RNASEL; the disease is viral infectious disease.