Then, we detected c11orf83 expression in IFNR1 or IFNR2 knock-out cells with or without viral infection, and examined transcriptional alternation of c11orf83 in the presence of type I IFN (IFNα and IFNβ) neutralizing antibodies (Supplementary Fig. S15 and Fig. 4). The gene discussed is IFNAR1; the disease is viral infectious disease.