Some of these TSGs, e.g., MLH1, SFRP4, CDKN2A, ZMYND10, APC, GSTP1 and PRDM2, and some imprinting genes, such as PEG3, SNRPN, KLF14, ATP10, H19, NDN, DLK1 and DIRAS3, were hypermethylated or hypomethylated in HCC tissue compared to adjacent tissue. The gene discussed is CDKN2A; the disease is hepatocellular carcinoma.