On the other hand, glycerolipid metabolism was down-regulated in response to dexmedetomidine, oxidative phosphorylation and neurodegenerative disease signalling were down-regulated in response to propofol, and PI3K-Akt signalling was inhibited in cells treated with dexmedetomidine or with propofol. The gene discussed is AKT1; the disease is neurodegenerative disease.